The severity of the erythema determines how this condition is handled. Erythema multiforme minor does not need to be treated because it is understood to resolve on its own. If your symptoms last longer than three to four weeks, your doctor may prescribe topical steroids.
The more severe type, Erythema multiforme major, necessitates intensive care. Bandages may be needed if the lesions are oozing a lot of fluid. Pressure relievers will be useful but it is often linked to a lot of pain. If the blisters continue to lose blood, the body can need to be refilled with intravenous fluids from an IV line in a hospital environment. If HSV is shown to be the cause of the reaction, antiviral drugs such as acyclovir may be recommended. Acyclovir is particularly important in preventing recurrent HSV-induced erythema multiforme. Antibiotics, on the other hand, would be administered if mycoplasma pneumonia is the cause of the skin reaction.